2592
ENDOTOXEMIA IN CHILDREN WITH CHRONIC
VIRAL HEPATITIS B Inoyatova F. I.,
Abdumadjidova Sh. U., Mukhamedov N.B., Inogamova G.B., Akhmedova A.Kh. Scientific Research
Institute of Pediatrics, Tashkent, Uzbekistan The purpose of our
investigation was to determine the interrelationship between clinical
course of chronic viral hepatitis B and severity degree of endotoxemia in
children. The main clinical
symptoms of endotoxemia were complaints of weakness and flaccidity, which were determined
in 91,3% of study children. All study children were divided into three
groups according to severity of clinical symptoms. Group 1 included
children with mild symptoms, group 2-children with moderate symptoms and
group 3-with severe symptoms. From clinical symptoms
syndrome of cholestasis was observed more frequently than others in
patients with endotoxemia of the 2nd.and 3d degree,
however,manifestation of this syndrome was lower than manifestation of
dyspeptic and hemorrhagic syndrome. Patients with chronic viral hepatitis
with high degree of endotoxemia were found dyspeptic syndrome (48,8%), this
is , evidently, associated with damage of detoxicational liver function and
damages of other organs of gastrointestinal tract. Hemorrhagic syndrome in
study children with toxemia of different degree was expressed moderately
and occurred with less frequency than dyspeptic syndrome. The manifestation
of mesenchyal-inflammatory syndrome depended on the degree of syndrome of
endotoxemia. Evaluation of the relation between hepatotropic syndrome and
syndrome of endotoxemia showed that this syndrome was more intensive in
children with endotoxemia of the 3d degree than of the 1st and 2nd
degree.
Interrelationship between cytolysis syndrome and endotoxemia was weaker
that dependence of mesenchyal-inflammatory syndrome, hemorrhagic syndrome,
and cholestatic syndrome on endotoxemia degree. In cases of chronic viral
hepatitis with syndrome of endotoxemia there was noted significant increase
in quantity of circulating immune complexes 5-7,5 times in our
observations. Conclusion: Syndrome
of endotoxemia had an effect on the clinical course of Viral hepatitis,
induced disorders in the immune system in these patients, that Resulted in progress
of chronic viral hepatitis B in these patients.