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ADVERSE EVENTS FOLOWING VACCINATION OF TYPHIM VI IN JAKARTA PRIMARY CHILD HEALTH CLINIC

Hartono Gunardi, Rini Sekartini, Soedjatmiko, Jeanne-Roos Ticoalu, Titi S Sularyo

Bagian Ilmu Kesehatan Anak FKUI-RSCM, Indonesia

Typhoid fever is still a community health problem related insufficient hygiene in developing countries. Preventive measures are improvement of environment sanitation, personal hygiene, hygienic food handling, and vaccine adminstration. Either oral or parenteral typhoid vaccine is to decrease incidence of typhoid morbidity. Typhim Vi is administered parenterally in children 2 years old or older. Adverse events following vaccination of Typhim Vi in Indonesian children is limited. This study is to investigate the adverse events following vaccination of Typhim Vi.

Methods: This was a cross sectional descriptive study. Subjects were healthy 2-5 years children visited Utan Kayu Baby Clinic during July 2000, or Kiara Family Physician Clinic during August 2000. Both clinics are located in Jakarta. Ten ml multidose Typhim Vi (hospital packed) was used. The fourth year pediatric resident administered half ml vaccine intramuscularly in anterolateral of femoral region. Single disposable syringe was used ounce only. Adverse events following vaccination were monitored by using modified Indonesian Vaccine Adverse Events Reporting System.

Results: Total of 196 children were studied, 55% of them were male. Adverse events following vaccination were local pain (44%), mild fever (12.7%), high fever (12%), local swelling (3%), vomiting (0.5%). Symptomatic treatment was given go those children.

Discussion: Adverse events following vaccination in this study were comparable to the previous studies. The most frequent adverse events were local pain and fever. Factor that might play a role in adverse event following vaccination was multidose vaccine.