2595
THE ROLE
OF UITRAFILTRATION WITH WHOLE BLOOD REPLACEMENT IN REDUCING THE ADVERSE
CARDIOPULMONARY EFFECTS OF SEPSIS IN SWINE MODEL Najeeb Al Othman,
Hussein Mukhtar, Damian Craig, George Quick, Ira Cheifetz, Jon Meliones Al Sabah
Hospital, Kuwait and Duke
University Medical Center, Durham, North Carolina, USA Objective: The purpose of this study was to evaluate the
effect of ultrafiltration in reducing the negative impact of sepsis on
cardiovascular function, and to determine whether the replacetnent of the
ultrafiltrate with whole blood provides beneficial mediators which may have
been removed during the ultrafiltration process. Design:
Despite recent advances in medicine,
patients who develop serious infections frequently die. This is a result of
the infections, the product they produce and the alterations in other
organs the infection cause. One postulate to help treat these infections is
by “cleaning” the blood through the use of a filter, While this has been
utilized in other diseases, it has not been used for patients with
infections. In addition, replacing the fluid with whole blood may even be
better in reversing the infections process. Setting:
This study was conducted at the Duke
University Medical Center, USA. Methods: Twenty-three swine (10-20kg) models randomized
to one of three groups: the
first group consisted of inducing sepsis without ultraliltration to
determine the spontaneous time course of the model; the second group
consisted of inducing sepsis, followed by Ultrafiltration and volume
replacement with mornal saline, and; the third group consisted of inducing
sepsis ,followed by ultrafiltration and volume replacement with whole
blood. Results: There were no noticeable improvements in any of
the cardiorespiratory variables studied after ultrafiltration with either
normal saline or whole blood replacement. Conclusion: The data obtained from this project will allow
us to develop new techniques that will help patients with these serious
infections.