2604

ONE CASE OF CHILD LEUKEMIA WITH THE CHROMOSOMAL ABNORMALITY OF t (6;17)

Feng XQ

Department of Pediatrics, Nanfang Hospital, Guangzhou, China

Objective: to report one case with a new chromosomal abnormality.

Methods: case analysis

Results: the patient, male, 8 years old, had got fever for more than one week with turgestent lymphoid nodes, hepatomegly and spleen tumor. The peripheral Blood routine was as follows: white cells 90.4×10⁹/L with the 95.5% of blast cells, Hb 134g/L, Plt 146×10⁹/L. The concentration of LDH in plasma was a high as 1417U/L. The FAB of subtype of morphologic classification is ALL-L2 and the blast cells is as more as 92.5%. The immunophenotyping indicates CD117, CD34, CD13, CD7, HLA-DR positive. The MDRI antigen is about 33% positive. The cloning chromosomal aberrations of t (6;17) was found in the cytogenetic analysis. The fusion gene of BCR/ABL was detected by the RT-PCR method, but the TCR gene rearrangement was not examined by the PCR method. The patient has poor response to prednisone, but he has got CR after induction chemotherapy of VDLP.

Conclusion: this case has one new chomosomal abnormality not reported yet in childhood leukemia with several poorly prognostic factors such as BCR/ABL gene positive, immune diplophentyping, poor response to prednisone. Therefore, this case belongs to the high risk ALL group.