EXPRESSION
OF PCNA, P53 GENE AND Bcl-2 GENE IN CHILDREN WITH ACUTE LEUKEMIA
AND ITS CLINICAL SIGNIFICANCE
Shi TX, Tang CHH,
Li SHJ, et al.
Department of Pediatrics, First Hospital,
Xinxiang Medical College, Weihuishi Henan Province, China
Objective: Acute leukemia (AL) of children is in the
first place in the incidence of children’s malignant tumors, and has
seriously affected children’s life and health. With the development of
chemotherapeutical drugs and improvement of chemotherapeutical scheme, the
standard and curative effect is continuously improved, but the resistance
of chemotherapeutic become the major factor of influcing the curative
effect. Much research has shown that cellular apoptosis is critical in
resistance to chemotherapeutic treatment for AL of children, so deep
research on cellular apoptosis will contribute to finding the reason of the
resistant drugs so as to take measures to increase the remission rate of
AL, and to prolong the patientes’ the survival time, and to disclose the pathologic
mechanism of AL of children.
There are a lot of factors of regulating cellular growth and proliferation
and apoptosis. Proliferating cells nuclear antigen ( PCNA) is reliable in
reflecting the cellular proliferative activity; P53, oncogene,
plays a neglective part in regulating the cellular proliferation, and its
mutant can inhibit the cellular apoptosis; Bcl-2 is a protocogene to
inhibit the apoptosis, and its excessive expression can prolong the
cellular life and maitain the cellular amounts. The aim of this paper is to
research the expression of PCNA、P53 ge ne、Bcl-2 gene and its
products in children with AL. The relationships of its positive expression
between types of AL, and changes of chromosome, remission stage and long
time of prognosis, were analyzed, to offer the basis of theory for AL with
children’s gene treatment.