2611

COAGULATION DISTURBANCES IN CHILDREN WITH SEPTICEMIA

Do Thi Minh Cam, Nguyen Cong Khanh, Cung Thi Ty

National Institute of Pediatric (Nip), Hanoi, Vietnam

Objective: Observation on the coagulation disturbances in children with septicemia.

Material and methods:

-73 children aging from 1 day to 13 year, among them 50 boys and 23 girl with sepsis were follow-up the coagulation disorders

-The coagulation status of the patiens was messured on the automatic coagulation analyser ACL 100. (PT-fibrinogen- APTT-TT and Seperated coagulation factors II, V, VII, X, VIII, IX, XI, XII)

-PLT counting on the automatic hematology analyser K 4500

-Latex D- Dimer test

Results:

-53 from total children had sepsis with Gram negative bacteria

(Klebsiella 30.1%, E. Coli1 5.1% and others)

-20 from total children had sepsis with Gram positive bacteria

( S. Aureus 21.9% and others)

The Coagulation disturbances were found:

+ Symptomatical thrombocytopenia in 41/73 (56.2%) of total cases. Among them 17 neonates have PLT less than 50×10⁹/l

+ Prolonged PT time in 44/73 (60.3%)

+ Prolonged APTT time in 43/73 (58.9%)

+ Prolonged Thrombin time in 28/73 (38.4%)

+ Low fibrinogen level (under 1.5 g/l) in 37/73 (50.7%).

+ D. dimer test positive in 37/73 (50.7%)

+ Low plasmatic factors 29/73 (40%).

+ DIC signs in 29/73 (39%)

Conclution:

-Coagulation disturbances occurred very commonly among children having sepsis in NIP

.The disturbances included thrombocytopenia, prolong PT, APTT, TT and reduced level of fibrinogen and factors in plasma.

-Children, who had sepsis with gram nagative bacteria got more severe coagulation disturbance than children, who had sepsis with gram positive bacteria.