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LIVER FUNCTION DISORDERS IN CHILDREN SUFFERING FROM DENGUE HAEMORRHAGE FEVER

Than Hong Anh, Dinh Thi Binh, Nguyen Kim Nu Hieu, Nguyen Quang Xuyen, Nguyen Hoang Yen

Tran Hung Dao General Hospital, Vietnam

Objective: of this study was to investigate clinical pictures and laboratory examinations in children suffering from Dengue haemorrhage fever (DHF) with liver function disorders.

Subject and method: 42 children with clinical DHF and confirmed by MAC-ELISA were included in this study. Liver function disorders were accessed by following parameters: SGOT, SGPT, Gros, Maclacgan were performed by Hitachi 704.Blood cell count were performed by CD-1700. Laboratory examinations were performed when admitted and convalescent period.

Results: Clinical and laboratory examination were performed for 42 children with DHF and we realised that: 76.8% of them had an increase of SGOT, 64.3% had an increase of SGPT. OF children patients with liver function disorders had high prevalence of haemorrhage, swelling liver, abdominal pain and early manifestation of shock comparing with patient group who had no function disorders (p<0.05 and p<0.01 respectively). Some haematological disorders such as serious decrease of white blood cell count (<4.0 G/L) and platelet (<100 G/L)were also noticed in group who had manifestation of liver function disorders.

Conclusion: Liver function disorders was a serious symptom in children with DHF and may lead to manifestations of shock. Intensive cares for these patients were needed and very important.