THE RESEARCH ABOUT THE DIAGNOSTIC VALUE OF CARDIAC TROPONIN I IN PEDIATRIC MYOCARDITIS AND CONTRAST WITH CK-MB

Zhou Haiying¹, Han Xiuzhen², Ma lixia¹, Liu Chunyu², Zhuang Jianxin²

1. Jinan Children’s Hospital, Jinan China

2. Shan Dong Hospital, Jinan China

Objective: The study evaluates the value of cTnI in the diagnosis of the pediatric myocarditis based on quantitative test of cTnI and CK-MB of 30 children with acute myocarditis, and makes a contrast with CK-MB.

Methods: cTnI is tested by ACS:180 Automated chemiluminescence’s system made by Bayer Co. CK-MB is tested by the Encord ^TH auto biochemistry-analytic system.

Results: 1. In the group of myocarditis, cTnI and CK-MB are significantly higher than those in the control group (p<0.001), 22 cases (making up 73%) have elevation of cTnI while 15 cases (making up 50%) have elevation of CK-MB. cTnI shows positive correlation with CK-MB (r=0.649). 2. After two weeks’ treatment, cTnI is still significantly higher than that in control group (p<0.001), but CK-MB shows no significant difference contrasting with that in control group (p>0.05). 3. Of the 13 cases with ST-T change in the group of myocarditis, 12 cases (making up 92%) have cTnI elevation while 6 cases (making up 46%) have CK-MB elevation.

Conclusion: 1. cTnI and CK-MB are both sensitive to the diagnosis of pediatric myocarditis. 2. The diagnostic time window of cTnI is wider than that of CK-MB.3.The specificity of cTnI reflecting cardiac injury is better than that of CK-MB.

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