THE LEVELS OF SERUM ANTI-GLIADIN IgG AND ANTIENDOMYSIUM ANTIBODIES IN ATOPIC CHILDREN

Yenigun A, Demir E, Tanac R, Gulen F, Can D, Kutuk,culer N

Division of Pediatrics Allergy and Respiratory Disease, Department of Pediatrics, Ege University School of Medicine, Izmir, Turkey

 

Objective: Celiac disease (CD) is resulted from intestinal system to gliadin fraction of gluten from wheat, barley, oats, rye. It is characterized villous atrophy and typical features of malabsorbtlon. CD can be found associated with both immunologic and non-immunologic diseases. The increased incidence of CD in children with type 1 diabetes mellitus, IgA deficiency, Down’s syndrome suggests possible immunologic factor in the development of celiac disease. The occurrence of atopy in CD has been reported whereas the prevalence of CD in atopy has not yet been established. Aim of study we wanted to investigate the levels of antigliadin and antiendomysium antibodies in atopic children. Also aim for that, it has been planned to compare between skin prick test of cereals polen the cereals of food allergy and the levels of serum antibodies.

Methods: In this study, 60 patients went under skin prick test with SAY products. Antiendomyslum were tested by indirect immunofluorescence  antigliadin IgG by ELISA.

Results: Patients were 43.3% asthma, 40% rhinitis, 10% asthma+rhinitis, 6.7% urticaria. Mean of ages were 11. The mean levels of antigliadin was 2.48 RU/ml (minimum:2, maximum:20). Antigliadin antibody was found in asthma 4.30±3.19, in rhinitis 4.27±3.94, in asthma+rhinitis 3.33±1.55 in urticaria 9.00±7.86. The levels of antiendomysium were negative all of patients. The cereals prick skin tests were found in asthma 11.5%, in rhinitis 20.9%, in asthma+rhinitis 33.3%, in urticaria 25% (+++). The prick test against cereals polen was found 69.2% inasthma, 95.8% in rhinitis, 100% in asthma+rhinitis, 50% in urticaria (+++) and (++++) positive. Rhinitis and asthma+rhinitis patients were found statistically significant (X2test p<0.05).

Conclusion: Antigliadin and antiendomyslum antibodies especially in atopic disease were not found significant. In both tests a p value of <0.05 was considered significant. As a result of this research patient who are sensitive tocereal food and cereal polen have not been found sensitive enough to celiac disease screen test antigliadin and antiendomyslum antibodies. These tests should have been on more patients who are suffering from celiac disease and atopic disease which might give positive results.

 

 
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