2676

RHEUMATIC FEVER PROPHY LAXIS AND STREPTOCOCAL INFECTIONS TREATMENT WITH PENICILLIN (BPG) AND PENICILLIN FAILURE

Ahmed Samir Kassem

Alexandria, Egypt

Rheumatic fever is a major health problem in Egypt. It is characterized by the tendency to recur following streptococcal infections for decades penicillin was used for prophylaxis.

Objective: To evaluate the efficacy of B.P.G. injection in Rheumatic fever prophy laxis & its failure.

Methods: comparative study between 2 regimens of Rh fever ptophy laxis B P G. every 2 weeks versus every 4 weeks. Study of the bio-availability of different brands of B.P.G.

Results: 2ry prophylaxis of R h fever requires discovery of R h cases and giving one B.P.G. every 15 days for each case. As the bioavailability studies have shown that penicillin disapears from the blood after B.P.G. injection in 14-17days, Comparing the two regimens of B.P.G. injection every 4 weeks versus every 2 weeks revealed that the 1st had double recurrence than the 2nd (0.12&0.06%). Different brands OF B.P.G. may differ in their pharmacokinitics.1 ry prophylaxis of Rh. fever requires discovery of G.A.B.S if and its treatment with penicillin penicillin is the first choice of treatment failure was reported rate of treatment failure was reported to be10-35%. The cause of this failure might be the presence of copathogens.

A group of drugs including cephalosporons erythromycin and others may help.

Conclusion: For 2 ry prophlaxis of R.F one B.P.G. should be given every.2 weeks. For primary prophylaxis one injection of B.P.G .is sufficient in case of G.A.B.S. infection failure of penicillin needs other effective drugs.