BIOLOGIC MARKERS IN BRONCHIOLITIS IN CHILDREN
NSh Valieva, SA Rakhimov, BT Ismatov
Tashkent Pediatric Medical Institute, Uzbekistan
Objective: The elaboration of methods of
diagnosing, fore casting of development and hardness of course of the
broncholitis on the basis of studying some biomarkers (HLA, blood group by
ABO, erytrocytar antigens on system Mn and P1, Cp
(cerruplazmine) and Hp (haptoglobin).
Methods: The biologic biomarkers have been studied among
the 114 children suffered from bronchiolitis at the age of from 1 month
till 3 years. The distribution of antigens, gystocombining with HLA were
implementing with helping of microlymphocitotokcik test of Terasaki. The
definition of the blood group by ABO has been implemented by standard
methods. The definition of the antigens P1 and Mn has also been
implementing with corresponding diagnostical antiserum.
Results: The results of distribution of the HLA-antigens
among the sick children were B7 (X2=8,22; P<0,01; OR-253) and
B27 (X2=6,16; P<0,02; OR=2,91), showed that in comparing of
the control group these antigens were trus worthy high. And at the same
time it was definite the HLA A2 antigen had negative links. During the
definition of belonging to blood group at the sick children with B (III)
blood group appeared more often (P<0,05), and among the sick children
with O (I) blood group appeared less seldom (P<0,001). During the
definition of the P1 antigen it was determined that the amount
of the sick children with this antigen decreased, and during the definition
of MN system the MN phenotype increased. During the definition Hp and Cp at
the sick children Hp1-1 and Cp AB much more found able and decreasing of Cp
B, during the definition of changing their quantity showed in children
suffered from bronchiolitis higher than healthy children and during the
treatment the frequency decreased.
Conclusion: All of the results showed that markers
had had links with bronchiolitis and bronchiolitis was developed by
prosperity way.