A STUDY ON THERAPEUTIC EFFECTS AND IMMUNITY MECHANISM OF TREATING BRONCHIOLITIS WITH DIFFERENT DOSAGE OF IVIG

Xu M1, Wu P2, Li XJ3, et al

1,2,3Chengdu Children’s Hospital, Chengdu, China

 

Objective: To verify the immunity function of bronchiolitic patients is disorder by observing the level of cytokines and to study the therapeutic effects of treating bronchiolitis with different do sage of IVIG.

Methods: The bronchiolitis patients were random divided into three groups: treatment group 1 (IVIG50mg/kg.day ×2day+anti-infective treatment+inhale O2) treatment group 2 (IVIG 200mg/kg.day×2day+anti-infective treatment+inhale O2). Control group (anti-infective treatment+inhale O2). Examined the levels of IL-2, IL-6, IgE before and after treatment and record theraputic effects.

Results: After treatment, the levels of IL-2 of treatment group 1 and 2 rised, the levels of IL-6, IgE of treatment group 1 and 2 dropped compared treatment groups with contral group (P<0.05), the levels were significantly different. Compared treatment group 1 with 2 (P<0.05), the levels were not significantly different.

Conclusion: Cytokine play a very important rote in the pathogenesis of bronchiolitis. IVIG not only kill virus directly but also play an important role in regaining to the function of T-cell and normal cytokine network. Small dosage of IVIG is effective, Forward investigation indicated that IVIG is an effective drug of meddling in infantile asthma early.

 
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