ANALYSIS ON THE
FUNCTION OF THE PITUI-TAPYADRENAL AXIS OF THE CHILDREN WITH REPEATED
RESPIRATORY INFECTION
Yu Xiuqing, Tang Guojin,
Zhao Xin
Tianjin Second Hospital,
Tianjin, China
Objective: Repeated respiratory
infection (RRI) is one kind of pediatric commonly encountered disease. We
analysed variety of the function of the pituitary-adrenal axis of the sick
children whom had been treated with glucocorticoid hormone, researched
rational administration in order to control RRI and improve the health status
of children.
Methods: 71 cases of RRI, and 35
cases of them are under 5 years of age, 36 of them between 5-12. In
28cases, routine dose of Prednisone (p.o) or Hydrocortisone (iv.dr) were
used, it is the hormone treatment group. The radio-immunity technique was
applied. All the subjects were sampled at 8-9 o’clock a.m, after
refrigerated contrifugation, 200ul of serum was conserved in refrigerator.
Results: In seven of the RRI
group, it was found that the concentration of serum cortisol had increased.
The difference of serum concentration of cortisol, ACTH between RRL group
and control group is insignificant. The result is identical between the age
groups. Comparing with the control group, the difference of concentrations
in insignificant (P<0.05). The frequence of episode, course of disease
and seriousness of illness are insignificant.
Conclusion: The reaction of this
axis is favorable in stress state. The secretion of glucocorticoid hormone
increases temporarily. It can’t change the axis to administer with
glucocorticoid, and the administration can’t improve the curative effect.
So glucocorti-Coid shouldn’t be used generally to RRI.