RELATIONSHIP
OF LEAD LEVEL UMBILICAL CORD BLOOD AND MECONIUM WITH NEONATAL
NEUROBEHAVIORAL DEVELOPMENT
YE Ping*, LIU Xiaoxian, KE Furong, et al.
* Department of Pediatrics, Medical
College, Wuhan University of Sicence and Technology, Wuhan, China
Objective: To explore the relationship of lead level in umbilical
cord blood (CBPb) and meconium (MPb) with their neurobehavioral development
in neonates with intrauterine exposure to lead at low level.
Method: level of
lead in umbilical cord blood and meconium were determined as indicators for intrauterine exposure
to lead , and neonatal
behavioral neurological assessment(NBNA) total score, and score of
non-biological auditory orientation
reaction(NBAOR),non-biological visual
orientation reaction(NBVOR) and
biological visual and auditory orientation reaction(BVAOR) as effect indicators, were determined for 103 randomiy
selected neonates delivered at the Department of Obstetrics and Gvnecology,
Wuhan First Metallurgical Constrction Company Hospital, Qingshan District
January to October 1999. A descriptively analysis was applied to evaluate
their correlationship.The neonates were divided into two groups with
high-and low-exposure based on the cutoff
value of CBPb of 0.483µmol/L
and MPb of 127.78mg/kg.
Result: There
was significant difference only in scores of NBNA(1 352.5
and 4 003.5)and BVAOR(1 310.5 and 4 045.5) between groups of high and low lead levels in
umbilical cord blood. There was no rank correlation between lead level of
umbilical cord blood and scores of NBNA,NBAOR,NBVOR and BVAOR.And ,there
was significant difference in scores of NBNA(1 636.0 and
3 720.0),NBAOR(2 110.5 and 3 245.5),BVAOR(1 828.5 and 3 527.5) and NBVOR(1 836.0 and 3 520.0) between groups of high and low meconium lead
levels .The level of lead in meconium correlated
reversely with scores of NBNA,NBVOR and BVAOR.
Conclusion: Level of lead in meconium could be used be used as a more
sensitive indicator for lead deposit in the fetal body during the period of
pregnancy.