THE EVALUATION OF DESMOPRESSIN IN TREATMENT OF
ADOLESCENT NOCTURNAL ENURESIS
Derman O1, Kanbur O. N1, Kinik E1
1 Hacettepe University, Ihsan Dogramaci
Children Hospital, Adolescent Unit, Ankara, Turkey
Objective:
Enuresis exits in adolescents can cause problem in social development and
relationship. Our goal is to determine the factors that predict the
effectiveness of desmopressin in the treatment of adolescent nocturnal
enuresis.
Methods: 20
adolescents (16 boys, 4 girls) with monosymptomatic nocturnal enuresis were
treated with oral desmopressin for 3 months, starting with 0.2 mg per oral
at night and controlling the symptoms every 2 weeks. After this period,
desmopressin was used the day alternatively and the dose was reduced
gradually. The treatment was completed for 6 months. Before treatment, a
range of variables (family history of enuresis, educational levels of
parents, number of children, first child in family, birth weight ) were
recorded. Urine osmolarity was evaluated for the effectiveness of
desmopressin treatment.
Results:
Disappearance of bedwetting by using desmopressin has been observed in
adolescent where they have a high urine osmolarity. We did not observe any
relapse during reducing desmopressin dose gradually, but after cessating the
treatment completely, relapses were begun to seen. Six months after the end
of the therapy, we can not find any patient who recover completely.
Conclusion:
Desmopressin seems to be effective in the treatment of primary enüresis
nocturnia during the period of treatment but during the long-term
follow-up, it is seen that the relapses were seen in all cases.