SOLID CYSTIC PAPILLARY TUMOR OF THE PANCREAS IN CHILDREN:
CLINICOPATHOLOGICAL STUDY OF NINE CASES AND LITERATURE REVIEW
Zhou Hong, Li Jiaju
Department of Surgery, Beijing Children¡¯s Hospital, Beijing, China
Objective: The current study attempts to estimate
the incidence and to examine the clinicopathological, immunohistochemical,
diagnostic and therapeutic features in children with SCPT of the pancreas
in Chinese population.
Methods: The diagnosis was confirmed by histology in all
nine patients. Routine pathological, histochemical, and immunohistochemical
methods were utilized to analyse the specimens. Representative blocks of
SCPT specimens were immunostained for NSE, a 1-AT, S-100, CgA, CK, EMA and insulin. The
features of SCPT in children reported in the English-language literature
were reviewed.
Results: There were 8 girls and 1 boys. The mean age was
11.1 years with an age range from 9 to 14 years. SCPTs accounted for 31.0%
of pancreatic tumors in Chinese children. The chief complains was abdominal
pain and palpable mass. The tumors were often located in the head of the
pancreas. The mean diameter of tumors was 8.7 cm. The procedures employed
included 6 local resection, 1 distal pancreatectomy and 2
pancreaticoduodenectomies. Post-poeratively, the patients were followed up
for 1 to 15 years and were alive. Histological examination showed solid
with cystic areas and papillary protrusions. Immunohistochemically, the
positive rates for were: a 1-AT 100%, NSE 57%,
S-100 33% and PAS 100%.
Conclusion: SCPT may be the second most common
pancreatic tumor in the Chinese pediatric population. Girls are more
frequently affected. The overall prognosis following surgical resection is
good. The pathological origin of the tumor remains unclear and requires
further investigations.
Key words: Pancreatic;
Neoplasms; Diagnosis; Immunohistochemistry