文本框: THE TRANSFORMATION OF BILIRUBIN PHOTO-ISOMERS IN JAUNDICED NEONATES TREATED BY BLUE LIGHT-EMITTING DIODE (LED) PHOTOTHERAPY Du Lizhong, Zhang Chenmei, Wang Jue Children’s Hospital, Zhejiang University, Hangzhou, China Objective: To evaluate the effects of a novel type of light source, the blue light-emitting diodes (LEDs), in phototherapy for neonatal hyper-bilirubinemia. Methods: Eighty-seven jaundiced premature infants were irradiated by the four light sources which were LEDs, single side conventional blue light (sCBL), LEDs+sCBL, double side conventional blue light (dCBL), respectively. The irradiance of LEDs was measured by a light meter at 380~520nm. Serum and urinary bilirubin isomers were determined with High-performance Liquid Chromatography (HPLC). Results: Serum 4Z,15 E-Bilirubin Ⅸα(ZE ) and Lumirubin (LR) in LEDs group after 6h of phototherapy were similar to those in sCBL’s [ ( 13.02±1.88 ) vs ( 13.36±2.23 ) and ( 3.94±0.98 ) vs ( 4.25±1.19 ) µmol/L, respectively ] ( P> 0.05 ). There were no significant difference between LEDs+sCBL and dCBL groups [ ( 21.94±2.27 ) vs ( 23.12±3.25 ) and ( 7.23±1.37 ) vs ( 7.53±1.38 ) µmol/L, respectively ] ( P> 0.05 ). There were significant difference between LEDs or sCBL and LEDs+sCBL or dCBLgroups (P<0.01), so were the serum ZE after 12h and total urinary LR excretion during 12h of phototherapy. There was no significant difference in the serum LR level within four groups after 12h of phototherapy. The side effects of LEDs phototherapy were not significant. Conclusions: Determination of bilirubin isomers quantitatively can estimate the efficacy of phototherapy, however analysis of urine LR is a non-invasive and much accurate option. The efficacy of LEDs is similar to sCBL in reducing serum bilirubin while the side effect is minimal. 2P-S5-3