The canine model of neurogenic bladder and its urodynamic evaluation

Chen F, Xie H, Liu G, Zhao H, Xu M, Xue H

Department of Peadiatric Urology, Xinhua Hospital, Shanghai Second Medical University, Shanghai, China

 

Objective: A canine model of neurogenic bladder was developed and evaluated by urodynamics.

Methods: 8 female dogs were divided into 2 groups: suprasacral and infrasacral. Spinal cord was transected at L6-7 level, and sacral cord was kept intact in suprasacral model while in infrasacral model it was destroyed completely. The urodynamic studies were performed in each dog at the time points of preoperation and 6 months postoperatively in both groups. The parameters were maximal bladder volume (BV), average bladder compliance (BC), maximal urethral pressure (UP) and maximal urethral closure pressure (UCP).

Results: After operation the dogs could never move their tail and keep their hips dry. Their latter limbs were flaccid paralysed and the abdomens dilated during the first week. But the activity of the latter limbs in both groups recovered slowly; the abdominal signs were only improved obviously in suprasacral dogs. In suprasacral group, BV and BC decreased by 37.78% and 53.33%, respectively, but UP (by 17.32%) and UCP (by 22.56%) increased significantly. While BV (by 89.31%) and BC (by 77.71%) of infrasacral dogs in 6 months after operation were higher than those before operation (P0.05).

Conclusion: The canine model showed both clinically and urodynamically the same characteristics as that in the neurogenic bladder after spinal shock. It can be used as a model in the research of neurogenic bladder.

 

 

 
2P-S7-1