|TWENTY-FOUR HOUR PROFILE OF BLOOD PRESSURE IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS AFTER ANTHRACYCLINE THERAPY|
|J. Šťastná, H. Hrstková, K. Krontorádová, Z. Nováková*, N. Honzíková*, B. Fišer*, E. Závodná*, 1-st Department of Paediatrics and * Department of Physiology, Masaryk University, Brno, Czech Republic|
The aim of the study: We followed late effect of anthracycline therapy on 24-hour profile of blood pressure in young oncological patients.
Methods: We examined
100 subjects. Former oncological patients (OP, number of subjects n=45)
after anthracycline treatment for acute lymphoblastic leukaemia (the mean
follow-up period – end of the treatment to ambulatory blood pressure
measurement: 9.7±3.1years; a total cumulative dose of anthracyclines
227±42mg/m2) were compared with the healthy subjects of an appropriate age
(Co, n=55). All subjects were divided into 3 groups according to the age:
children (13-15 years) - OP:n=10, Co:n=9; adolescents (16-18 years) -
OP:n=20, Co:n=23; and young adults (19-21 years) - OP:n=15, Co:n=23.
Results: The statistical significant difference between OP and Co was found during the night hours (20 p.m.–2.a.m.) in the group of 19-21 years old only. The mean values of systolic blood pressure from this period were 104.6±9.3 mmHg in OP and 117.8±12.3mmHg in Co (p<0.01) and diastolic blood pressure were 58.2±7.2 mmHg in OP and 67.7±10.4 mmHg in Co (p<0.01).
Conclusion: It is concluded that several years after anthracycline treatment, the values of blood pressure at night are lower than in healthy subjects. This indicates an impairment of the sympathetic nervous system activity.
Supported by grants: VVZ MSMT No. 0021622402.