14th Meeting of Paediatric Research of Central European Countries

	14th Meeting of Paediatric Research of Central European Countries Prague, Czech Republic, Friday, June 17th, 2005
	Programme

8,20		Introduction on behalf of the local organisers: Prof. Jan Janda, MD

		Welcome greetings: Prof. Josef Koutecký, MD, Dean of the 2^nd Medical School, Charles University Prague

8.30 - 10.35		Oral presentations:
	1	MLL rearrangements predominantly occur in CD10–/CDw65+/CD15+ childhood pro-B and pre-B acute lymphoblastic leukemia (ALL) Attarbaschi Andishe, Georg Mann, Margit König, Manuel Steiner, Sabine Strehl, Björn Schneider, Anita Schreiberhuber, Arndt Borkhardt, Rolf Marschalek, Winfried Pickl, Thomas Lion, Helmut Gadner, Oskar A. Haas and Michael Dworzak, St. Anna Children’s Hospital, Vienna, Austria
	2	NO assOCatiOn between Insulin-like growth factor I receptor G3174A polymorphism with retinopathy of prematurity Balogh Ádám ¹, László Derzbach¹, Géza Bokodi¹, Ádám Vannay¹, András Treszl¹, and Barna Vásárhelyi² ¹)1^st.fDepartment of Pediatrics Semmelweis University, Budapest, Hungary, ²)Res. Lab. of Pediatrics and Nephrology, Hungarian Academy of Science
	3	NOMID (CINCA) SYNDROME ASSOCIATED WITH A NEW MUTATION, 1783A->G, SER595GLY, IN THE CIAS1/NALP3 GENE *MöllerJ*, J. Roesler, M. Kanariou, V. Schuster, C. Dracou, A. Rösen-Wolff, & M. Gahr* )Department of Pediatrics, University Clinic “Carl Gustav Carus”, Dresden, Germany, ) Paediatric Rheumatology Outpatient's Clinic, 2nd Paediatric Dept., 'P&A Kyriakou' Children's Hospital, Athens, Greece, **) Department of Pediatrics, University of Leipzig, Leipzig, Germany
	4	Protein microarray analysis – a suitable tool for detection of autoreactive peripheral blood mononuclear cells in type 1 diabetes patients Vrabelova Z.¹, Stechova K.¹, Sumnik Z.¹, Bohmova K.¹, Chudoba D.²,Pechova M.³, Vavrinec J.¹ , 2^ndMedical Faculty of Charles University and University Hospital Motol, Prague, the Czech Rep., ¹) Paediatric dpt., ²) Dpt.of Biology and Genetics, ³) Biochemistry Dept.
	5	Immunomodulatory cApacity of milk derived acidic oligosaccharide fractions on cord blood mononuclear cells Eiwegger Thomas¹, Bernd Stahl², Joachim Schmitt², Günther Boehm², Paul Haidl¹, Eleonora Dehlink¹, Radvan Urbanek¹, Zsolt Szépfalusi¹, ¹) Dept. of Pediatrics and Juvenile Medicine, Div. Of General Pediatrics, Medical University of Vienna, Vienna, Austria, ²) Numico Research Germany, Friedrichsdorf, Germany
	6	CLINICAL PICTURE VERSUS DNA DIAGNOSTICS IN MODY 3 AND MODY2 Staník J.¹, D. Gašperíková², Ľ. Barák¹, M. Hučková², M. Kuseková³, M. Pašková⁴, V. Doničová⁵, B. Milošovičová⁶, Z. Schroner⁷, N. Mišovicová⁸, E. Śeböková², J. Michálek⁹, M. Benedeková¹, I. Klimeš² ¹) I^st Dept. of Pediatrics, Children University Hospital ²) DIABGENE, Institute of Experimental Endocrinology, Bratislava;, ³) I^st and ⁴) I^nd Dept. of Pediatrics, Children University Hospital and ⁵) Diabetes Outpatient Clinic, Košice; ⁶) A. Getlik’s Dept. of Pediatrics, Bratislava,⁷) Diabetes Outpatient Clinic, Moldava/Bodvou, ⁸) Jessenius Faculty School of Medicine, Martin, ⁹) National Institute for Diabetes & Endocrinology, Lubochňa

10. 35 - 11.00		Coffee break

11.00 - 11.30		Invited speaker lecture: Prof. Milan Macek Jr., MD, Dept. of Biology and Medical Clinical Genetics, University Hospital Motol CYSTIC FIBROSIS - A MODEL OF MOLECULAR PATHOGENESIS

11.30 - 13.00		Oral presentations:
	7	INCREASED EXPRESSION OF TOLL-LIKE RECEPTOR 2 (TLR2) AND TLR4 IN COELIAC DISEASE Szebeni Beate¹, Veres G.², Dezsőfi A.², Rusai Krisztina¹, Vannay Á¹, Tulassay T.², Arató András² ¹) Research Group for Paediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary. ²) First Department of Paediatrics, Semmelweis University, Budapest, Hungary.
	8	Antiangiogenic therapy by dual targeting of VEGF-R2 and Tie-2 using bispecific, tetravalent intradiabodies Jendreyko Nina^{1, 2}, Mikhail Popkov², Christoph Rader², Carlos F. Barbas III², Gerhard Gaedicke¹ ¹) Department of Pediatrics, Charité, Augustenburger Platz 1, 13353 Berlin, Germany; ²) The Scripps Research Institute, Dept. of Mol. Biology, La Jolla, USA
	9	THE SER128ARG E-SELECTIN AND THR715PRO P-SELECTIN POLYMORPHISMS AND RISK AND CHARACTERISTICS OF PREECLAMPSIA Derzbach László^a, Ádám Balogh^a, Géza Bokodi^a, Andrea Fekete^a, János Rigó Jr.^b, Tivadar Tulassay^a,c ^a) 1^st. Department. of Pediatrics, Semmelweis University,^b) 1^st. Department of Obstetrics and Gynecology Semmelweis University, ^c) Research Laboratory of Pediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary
	10	GENE DEFECTS IN PATIENTS WITH GROWTH HORMONE DEFICIENCY: RESULTS OF A CZECH NATIONAL STUDY Vosahlo J.¹, Pfaeffle RW. ², Stobbe H. ², Lebl J.¹ and the Workshop on Growth Hormone of the Czech Society for Endocrinology³ ¹) Department of Paediatrics of 3^rd Faculty of Medicine, Charles University, Prague, Czech Republic, ²) University Children's Hospital, Leipzig, Germany, ³) Leaders of centres for treatment with growth hormone from the Czech Republic

13.00 - 14.15		Lunch break

14.15 - 16. 20		Oral presentations:
	11	Immunophenotype analysis in pediatric patients with SLE nephritis treated with rituximab, prednison and mycophenolate Edelbauer M, Jungraithmayr T, Zimmerhackel LB, University Dptm. of Pediatrics, Innsbruck, Austria
	12	The role of neuronal nitric oxide synthase (nNOS) inhibition in renal ischemia-reperfusion injury Rusai Krisztina¹, Veronika Müller², Adam Vannay¹, Andrea Fekete¹, Beata Szebeni¹, Ondrej Viklicky³, Tivadar Tulassay¹, Gyorgy Reusz¹, Attila J Szabó¹ ¹)Semmelweis University, Ist Dep. of Pediatrics, ²) Dep. of Pulmonology, ³) IKEM Prague Dep. of Nephrology
	13	Longitudinal observation of enterovirus and adenovirus in stool samples from Norwegian infants Cinek Ondřej¹, E. Witsø², S. Jeansson³, T. Rasmussen², P. Drevinek¹, T. Wetlesen², J. Vavrinec¹, B. Grinde², K.S. Rønningen² ¹) Motol University Hospital, Prague, The Czech Republic; ²) Norwegian Institute of Public Health, Oslo, Norway; ³) Ullevĺl University Hospital, Oslo, Norway
	14	Epithelial-mesenchymal transdifferentiation and the stress response in pediatric peritoneal dialysis Vargha Regina, Michaela Endemann, Andrea Riesenhuber, Klaus Arbeiter, Kurt Herkner and Christoph Aufricht, University Children Hospital, Vienna, Austria
	15	UREMIC AUTONOMMIC DYSFUNCTION: ROLE OF SYMPATHETIC OVERACTIVITY Tory K., Horváth E., Süveges Zs., Fekete A., Sallay P., Tulassay T., Reusz GS, First Dept. of Paediatrics, Semmelweis University Budapest
	16	MEASUREMENT OF THE EPSTEIN-BARR-VIRUS (EBV)-SPECIFIC-CYTOTOXIC T-CELLS AFTER PEDIATRIC SOLID ORGAN TRANSPLANTATION Stiller B.¹, Kern H.¹, Ehammer Z.¹, Hollander S.², Wiesmayr S.¹, Larcher C.³ , Maecker B.² , Klein C.², Zimmerhackl LB.^{1 1}) Department of Pediatrics, Medical University Innsbruck; Austria, ²) Department of Pediatric Haematology and Oncology; Hannover Medical School; Germany, ³) Institute for Hygiene and Social Medicine; Medical University Innsbruck; Austria

		Coffee break

16.20 -16. 40		Posters presentations
		Discussion individual during the coffeee breaks, during the lunch break the poster walk and after the last oral presentation some authors of selected poster will be asked to present a short summary with 5 minutes power-point presentation
	17	autoimmune mechanisms in cystic fibrosis pathogenesis Böhmová K.¹, Stechova K.¹, Vrabelova Z.¹,Sumnik Z.¹, Chudoba D.², Pechova M.³, Cinek O.¹, Vavrinec J.¹, 2^nd Medical Faculty of Charles University and University Hospital Motol, Prague, the Czech Rep. ¹) Paediatric dpt., ²) Dpt.of Biology and Genetics, ³) Biochemistry Dpt
	18	THE ASSOCIATION OF THE TNF-α -308 A ALLELE WITH THE DURATION OF OXYGEN SUPPLEMENTATION IN PRETERM NEONATES Bokodi Géza¹, András Treszl¹, László Derzbach ¹, Tivadar Tulassay ^1,2, Barna Vásárhelyi ² ¹) First Department of Pediatrics, Semmelweis University, ²) Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences
	19	RECTROSPECTIVE ANALYSIS OF INVASIVE MENINGOCOCCAL DISEASES IN CHILDREN (1999 – 2003) Bronská Eva^1,2, O. Dzupova³, V. Maresova¹, K. Soltysova¹ ¹) First Dptm. of Infectious Diseases, 2^nd Medical School, University Hospital Bulovka, Prague, ²) National Reference Laboratory for Meningococcal Infections, National Institute of Public Health, Prague, ³) Dptm.of Infectious Diseases, 3rd Medical School, University Hospital Bulovka, Prague, Czech Republic
	20	Immunoreactive adiponectin in serum of Obese Children Bronský J.^1,2, Šrámková D^.3, Pechová M.², Průša R. ², and Nevoral J.¹ ¹) Paediatric Clinic, Charles University, 2^nd Medical Faculty and University Hospital Motol, Prague, Czech Republic, ²) Department of Clinical Biochemistry and Pathobiochemistry, Charles University, 2^ndMedical Faculty and University Hospital Motol, Prague, Czech Republic, ³) Institute of Endocrinology, Prague, Czech Republic
	21	CYP21 GENOTYPE AND SEVERITY OF VIRILIZATION IN GIRLS WITH CONGENITAL ADRENAL HYPERPLASIA (cah) Gács Zs., Ferenczi A, 2^nd Dept. of Pediatrics, Semmelweis University, Budapest, Hungary
	22	Aerosolized Anakinra: potential role in the prevention of bronchopulmonary dysplasia? Chada Martin, Stephanie Nögel, Ana-Marija Cubra, Aline Rückel, Katharina von der Hardt, Julia Walther, Jörg Dötsch, Wolfgang Rascher, and Michael A. Kandler, Klinik für Kinder und Jugendliche, Universitätsklinikum Erlangen-Nürnberg
	23	Examination of anti-apoptic heat-shock proteins as progmnostic factors in medulloblastoma/pnet Hauser Péter MD¹, Zoltán Hanzély MD², Zsuzsanna Jakab MD, PhD¹, Lászlóné Oláh³, András Jeney MD, PhD, DSc³, Dezső Schuler MD, DSc, FRCP¹, László Bognár MD, PhD², Miklós Garami MD¹ ¹) 2^nd Department of Pediatrics, Semmelweis University, Budapest, Hungary ²) National Institute of Neurosurgery, Budapest, Hungary ³) 1st Department Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary 1
	24	THE ROLES OF GALECTINS IN THE PATHOGENESIS OF ASTHMA IN AN ANIMAL MODEL SYSTEM Kozma Gergely T.¹, Éva Pállinger², Csaba Ádori⁴, Zsolt Komlósi³, Edit Buzás², Péter Kovács ², Csaba Szalai², András Szabó¹, András Falus², Tivadar Tulassay¹, Ádám Vannay¹ ¹)1^st Department of Pediatrics, Semmelweis University and Research Group for Paediatrics and Nephrology, Hungarian Academy of Scineces, Hungary; ²) Department of Genetics, Cell and Immunobiology, ³) Department of Pulmonology, Semmelweis University, Hungary; ⁴) General Zoology, Eötvös University of Sciences, Hungary
	25	Promotor polymorphisms of interleukin 13 are asSociated with bronchial asthma and juvenile idiopathic arthritis Maas Sibylle, Reinhard Berner, Klaus Deichmann, Andrea Heinzmann University Children’s Hospital, Mathildenstr. 1, D-79106 Freiburg, Germany
	26	AUTOIMMUNE OVARIAN DAMAGE Kosová H.¹, Hořejší J.¹, Martínek J.², ¹)Dept. of Pediatric and Adolescent Gynecology, 2nd Medical School, ²) Inst. Histology Embryology, 1^st Medical School, Charles University Prague, Czech Republic
	27	SURFACE MARKERS IN CORD BLOOD OF NEONATES AT RISK FOR EARLY INFECTION ACTIVATION LEUKOCYTE Rozsíval P., E. Parizkova / University Hospital Hradec Kralove / Dept. of Pediatrics, D. Vokurková / University Hospital Hradec Kralove / Institute of Clinical Immunology and Allergology, Czech Republic
	28	Endocrine and Metabolic Causes of Sudden Death in Infancy Strnadová Kristina^1,3, Felix Votava¹, Jan Lebl¹, Ivan Bouška², Franz Waldhauser³, Olaf Bodamer³, Toni Torresani⁴, ¹)Dept. of Pediatrics, 3^rd Faculty of Medicine, Charles University, Prague, ²)Dept. of Forensic Medicine, 2^nd Faculty of Medicine, Charles University, Prague, ³)Dept. of Pediatrics, Children´s University Hospital, Vienna, ⁴)Dept. of Endocrinology, University Children´s Hospital, Zurich
	29	The reduction of cholesterol levels by probiotic bacteria Székyová D.¹, Dobias J.², Ebringer L.², Kovács L.¹ ¹) 2^nd Department of Pediatrics, Comenius University Medical School, University Children’s Hospital, Bratislava, ²) Institute of Cell Biology, Faculty of Natural Sciencies, Comenius University, Bratislava
	30	The role of two polymorphisms in candidate genes in young patients with hypertension Varda Nataša Marčun¹, Boris Zagradišnik², Špela Stangler Herodež², Nadja Kokalj Vokač², Alojz Gregorič¹, ¹)Dep.of Paediatrics and ²) Medical Genetics, Maribor Teaching Hospital, Maribor, Slovenia
	31	ENDOTHELIAL FUNCTION IN ESSENTIAL AND WHITE COAT HYPERTENSION Mráz, M.¹, Spurný, P.², Potočeková, D.³, Olexa, P.², Podracká, Ľ.¹ ¹) 1^-st Department of Paediatrics, Šafárik University, Košice, Slovakia
	32	AGE RELATED CHANGES OF BAROREFLEX SENSITIVITY IN CHILDREN AND ADOLESCENTS E. Zavodna, *H. Hrstkova, Z. Novakova, B. Fiser, N. Honzikova, Department of Physiology and First Department of Paediatric Internal Medicine, Faculty of Medicine, Masaryk University in Brno, Czech Republic
	33	Effect of triiodothyronine (T3) on excitotoxic brain damage of newborn mice Gergely Sárközy^1,2, Georg Simbruner¹, He Xiagying^1;3, Martina Urbanek¹, Pierre Gressens⁴, Matthias Keller¹ ¹) Department of Neonatology, Medical University Innsbruck, Austria, ²) 2nd Department of Pediatrics, Semmelweis University Budapest, Hungary, ³) Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China 4 INSERM, Hopital Robert Debre, Paris, France